When deciding between starting Christian McCaffrey or James Cook, here are some key insights based on their current status and performance potential:

Christian McCaffrey

• Team: San Francisco 49ers
• Experience: 8 years in the NFL
• Depth Chart Position: RB1
• Injury Status: No current injury notes or status updates.
• Fantasy Outlook: McCaffrey is known for his dual-threat ability as both a runner and a receiver. He has consistently been a top fantasy performer when healthy, and being the primary back in a high-powered offense like the 49ers enhances his value.

James Cook

• Team: Buffalo Bills
• Experience: 3 years in the NFL
• Depth Chart Position: RB1
• Injury Status: No current injury notes or status updates.
• Fantasy Outlook: Cook has shown promise as a versatile back, particularly in the passing game. However, he may not have the same level of consistent production as McCaffrey, especially in high-stakes matchups.

Recommendation

Given McCaffrey's extensive experience, established role as the lead back, and the offensive strength of the 49ers, he is generally the safer and more reliable choice for your starting lineup. While James Cook has potential, especially in a dynamic Bills offense, McCaffrey's track record and ability to contribute in multiple ways make him the preferable option.

If you have any specific matchups or scoring settings to consider, feel free to share, and I can provide more tailored advice!